Eric Dane, best known for his role as Dr. Mark Sloan on Grey’s Anatomy, has died at the age of 53 after battling ALS. His representative confirmed that he passed away peacefully, surrounded by his wife and two daughters.
Dane had publicly shared his diagnosis of amyotrophic lateral sclerosis in 2025. Over the past year, he became a strong voice for ALS awareness while continuing to work in Hollywood despite serious physical challenges.
A Brave Fight Against ALS
ALS, also known as Lou Gehrig’s disease, is a rare and progressive condition that affects nerve cells in the brain and spinal cord. Over time, patients lose muscle control. Dane revealed that he had lost the use of his right arm as the disease progressed.
Even as his physical strength declined, Dane remained determined. Speaking at public events, he said he wanted to keep working as long as he could. “I still have my brain and my speech,” he shared in one appearance. “I’m grateful I can still work in any capacity.”
He also became an advocate, using his platform to raise awareness and push for more research funding.
The Legacy of ‘McSteamy’
Dane first appeared on Grey’s Anatomy in 2006 as Dr. Mark Sloan, quickly earning the nickname “McSteamy.” His character became a fan favorite for his charm, confidence and emotional depth.
He was a series regular from Seasons 3 to 8 and returned briefly in 2021. His on-screen romance with Lexie Grey and close friendship with Derek Shepherd made him one of the show’s most memorable stars.
After leaving the series, Dane led the TNT drama The Last Ship and later appeared in HBO’s Euphoria. In one of his final performances, he portrayed a firefighter diagnosed with ALS on NBC’s Brilliant Minds — a role that deeply moved cast and crew.
Tributes and Family
Dane is survived by his wife, actress Rebecca Gayheart, and their daughters, Billie and Georgia.
Colleagues and fans have described him as brave, generous and deeply committed to his family. In one of his final public messages, Dane said he hoped to see his daughters grow up and promised to “fight until the last breath.”
Though his life was cut short, Eric Dane leaves behind a powerful legacy — not just as a beloved television star, but as a courageous advocate who faced a devastating illness with honesty and strength.